Shafa Orthopedic Journal

Published by: Kowsar

Non-Union Current Treatment Concept

Arash Moghaddam 1 , * , Claudia Ermisch 1 and Gerhard Schmidmaier 1
Authors Information
1 Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital Heidelberg, Heidelberg, Germany
Article information
  • International Journal of Medical Education: February 28, 2016, 3 (1); e4546
  • Published Online: February 20, 2016
  • Article Type: Review Article
  • Received: October 31, 2015
  • Accepted: December 25, 2015
  • DOI: 10.17795/soj-4546

To Cite: Moghaddam A, Ermisch C, Schmidmaier G. Non-Union Current Treatment Concept, Shafa Ortho J. 2016 ;3(1):e4546. doi: 10.17795/soj-4546.

Abstract
Copyright © 2016,Iran University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
Footnote
References
  • 1. Einhorn TA. The cell and molecular biology of fracture healing. Clin Orthop Relat Res. 1998; (355 Suppl)-21[PubMed]
  • 2. Schmidmaier G, Schwabe P, Wildemann B, Haas NP. Use of bone morphogenetic proteins for treatment of non-unions and future perspectives. Injury. 2007; 38 Suppl 4-41[PubMed]
  • 3. Giannoudis PV, Einhorn TA, Schmidmaier G, Marsh D. The diamond concept--open questions. Injury. 2008; 39 Suppl 2-8[DOI][PubMed]
  • 4. Rothman RH, Klemek JS, Toton JJ. The effect of iron deficiency anemia on fracture healing. Clin Orthop Relat Res. 1971; 77: 276-83[PubMed]
  • 5. Moghaddam A, Zimmermann G, Hammer K, Bruckner T, Grutzner PA, von Recum J. Cigarette smoking influences the clinical and occupational outcome of patients with tibial shaft fractures. Injury. 2011; 42(12): 1435-42[DOI][PubMed]
  • 6. Keating JF, O'Brien PI, Blachut PA, Meek RN, Broekhuyse HM. Reamed interlocking intramedullary nailing of open fractures of the tibia. Clin Orthop Relat Res. 1997; (338): 182-91[PubMed]
  • 7. Clifford RP, Lyons TJ, Webb JK. Complications of external fixation of open fractures of the tibia. Injury. 1987; 18(3): 174-6[PubMed]
  • 8. Ruedi TP, Luscher JN. Results after internal fixation of comminuted fractures of the femoral shaft with DC plates. Clin Orthop Relat Res. 1979; (138): 74-6[PubMed]
  • 9. Wolinsky PR, McCarty E, Shyr Y, Johnson K. Reamed intramedullary nailing of the femur: 551 cases. J Trauma. 1999; 46(3): 392-9[PubMed]
  • 10. Ricci WM, Bellabarba C, Evanoff B, Herscovici D, DiPasquale T, Sanders R. Retrograde versus antegrade nailing of femoral shaft fractures. J Orthop Trauma. 2001; 15(3): 161-9[PubMed]
  • 11. Kontakis GM, Papadokostakis GM, Alpantaki K, Chlouverakis G, Hadjipavlou AG, Giannoudis PV. Intramedullary nailing for non-union of the humeral diaphysis: a review. Injury. 2006; 37(10): 953-60[DOI][PubMed]
  • 12. Rommens PM, Kuechle R, Bord T, Lewens T, Engelmann R, Blum J. Humeral nailing revisited. Injury. 2008; 39(12): 1319-28[DOI][PubMed]
  • 13. Wright RR, Schmeling GJ, Schwab JP. The necessity of acute bone grafting in diaphyseal forearm fractures: a retrospective review. J Orthop Trauma. 1997; 11(4): 288-94[PubMed]
  • 14. Wei SY, Born CT, Abene A, Ong A, Hayda R, DeLong WG, Jr. Diaphyseal forearm fractures treated with and without bone graft. J Trauma. 1999; 46(6): 1045-8[PubMed]
  • 15. Ring D, Allende C, Jafarnia K, Allende BT, Jupiter JB. Ununited diaphyseal forearm fractures with segmental defects: plate fixation and autogenous cancellous bone-grafting. J Bone Joint Surg Am. 2004; 86-a(11): 2440-5[PubMed]
  • 16. Richard MJ, Ruch DS, Aldridge JM, 3rd. Malunions and nonunions of the forearm. Hand Clin. 2007; 23(2): 235-43[DOI][PubMed]
  • 17. Krzykawski R, Krol R, Kaminski A. The results of locked intramedullary nailing for non-union of forearm bones. Ortop Traumatol Rehabil. 2008; 10(1): 35-43[PubMed]
  • 18. Moghaddam-Alvandi A, Zimmermann G, Buchler A, Elleser C, Biglari B, Grutzner PA, et al. [Results of nonunion treatment with bone morphogenetic protein 7 (BMP-7)]. Unfallchirurg. 2012; 115(6): 518-26[DOI][PubMed]
  • 19. Gaston MS, Simpson AH. Inhibition of fracture healing. J Bone Joint Surg Br. 2007; 89(12): 1553-60[DOI][PubMed]
  • 20. Moghaddam A, Weiss S, Wolfl CG, Schmeckenbecher K, Wentzensen A, Grutzner PA, et al. Cigarette smoking decreases TGF-b1 serum concentrations after long bone fracture. Injury. 2010; 41(10): 1020-5[DOI][PubMed]
  • 21. McKibbin B. The biology of fracture healing in long bones. J Bone Joint Surg Br. 1978; 60-B(2): 150-62[PubMed]
  • 22. Tonna EA. Histologic and histochemical studies on the periosteum of male and female rats at different ages. J Gerontol. 1958; 13(1): 14-9[PubMed]
  • 23. Macey LR, Kana SM, Jingushi S, Terek RM, Borretos J, Bolander ME. Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am. 1989; 71(5): 722-33[PubMed]
  • 24. Cruess RL, Sakai T. Effect of cortisone upon synthesis rates of some components of rat bone matrix. Clin Orthop Relat Res. 1972; 86: 253-9[PubMed]
  • 25. Schoierer O, Bloess K, Bender D, Burkholder I, Kauczor HU, Schmidmaier G, et al. Dynamic contrast-enhanced magnetic resonance imaging can assess vascularity within fracture non-unions and predicts good outcome. Eur Radiol. 2014; 24(2): 449-59[DOI][PubMed]
  • 26. Bode G, Strohm PC, Sudkamp NP, Hammer TO. Tibial shaft fractures - management and treatment options. A review of the current literature. Acta Chir Orthop Traumatol Cech. 2012; 79(6): 499-505[PubMed]
  • 27. Calori GM, Phillips M, Jeetle S, Tagliabue L, Giannoudis PV. Classification of non-union: need for a new scoring system? Injury. 2008; 39 Suppl 2-63[DOI][PubMed]
  • 28. Abumunaser LA, Al-Sayyad MJ. Evaluation of the calori et Al nonunion scoring system in a retrospective case series. Orthopedics. 2011; 34(5): 359[DOI][PubMed]
  • 29. Pneumaticos SG, Panteli M, Triantafyllopoulos GK, Papakostidis C, Giannoudis PV. Management and outcome of diaphyseal aseptic non-unions of the lower limb: a systematic review. Surgeon. 2014; 12(3): 166-75[DOI][PubMed]
  • 30. Calori GM, Colombo M, Mazza EL, Mazzola S, Malagoli E, Marelli N, et al. Validation of the Non-Union Scoring System in 300 long bone non-unions. Injury. 2014; 45 Suppl 6-7[DOI][PubMed]
  • 31. Roussignol X, Currey C, Duparc F, Dujardin F. Indications and results for the Exogen ultrasound system in the management of non-union: a 59-case pilot study. Orthop Traumatol Surg Res. 2012; 98(2): 206-13[DOI][PubMed]
  • 32. Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: the diamond concept. Injury. 2007; 38 Suppl 4-6[PubMed]
  • 33. Calori GM, Colombo M, Mazza E, Ripamonti C, Mazzola S, Marelli N, et al. Monotherapy vs. polytherapy in the treatment of forearm non-unions and bone defects. Injury. 2013; 44 Suppl 1-9[DOI][PubMed]
  • 34. Giannoudis PV, Calori GM, Begue T, Schmidmaier G. Bone regeneration strategies: current trends but what the future holds? Injury. 2013; 44 Suppl 1-2[DOI][PubMed]
  • 35. Giannoudis PV, Ahmad MA, Mineo GV, Tosounidis TI, Calori GM, Kanakaris NK. Subtrochanteric fracture non-unions with implant failure managed with the "Diamond" concept. Injury. 2013; 44 Suppl 1-81[DOI][PubMed]
  • 36. Calori GM, Colombo M, Ripamonti C, Bucci M, Fadigati P, Mazza E, et al. Polytherapy in bone regeneration: clinical applications and preliminary considerations. Int J Immunopathol Pharmacol. 2011; 24(1 Suppl 2): 85-90[PubMed]
  • 37. Pountos I, Georgouli T, Pneumaticos S, Giannoudis PV. Fracture non-union: Can biomarkers predict outcome? Injury. 2013; 44(12): 1725-32[DOI][PubMed]
  • 38. Calori GM, Giannoudis PV. Enhancement of fracture healing with the diamond concept: the role of the biological chamber. Injury. 2011; 42(11): 1191-3[DOI][PubMed]
  • 39. Moghaddam A, Zietzschmann S, Bruckner T, Schmidmaier G. Treatment of atrophic tibia non-unions according to 'diamond concept': Results of one- and two-step treatment. Injury. 2015; 46 Suppl 4-50[DOI][PubMed]
  • 40. Giannoudis PV, Jones E, Einhorn TA. Fracture healing and bone repair. Injury. 2011; 42(6): 549-50[DOI][PubMed]
  • 41. Schmidmaier G, Schwabe P, Strobel C, Wildemann B. Carrier systems and application of growth factors in orthopaedics. Injury. 2008; 39 Suppl 2-43[DOI][PubMed]
  • 42. Dinopoulos C. Re: The article "Dinopoulos H, Dimitriou R, Giannoudis PV. Bone graft substitutes: what are the options? Surgeon. 2012 Aug;10(4):230-9. Surgeon. 2013; 11(5): 293[DOI][PubMed]
  • 43. Kouroupis D, Baboolal TG, Jones E, Giannoudis PV. Native multipotential stromal cell colonization and graft expander potential of a bovine natural bone scaffold. J Orthop Res. 2013; 31(12): 1950-8[DOI][PubMed]
  • 44. Kanakaris NK, Morell D, Gudipati S, Britten S, Giannoudis PV. Reaming Irrigator Aspirator system: early experience of its multipurpose use. Injury. 2011; 42 Suppl 4-34[DOI][PubMed]
  • 45. Cox G, McGonagle D, Boxall SA, Buckley CT, Jones E, Giannoudis PV. The use of the reamer-irrigator-aspirator to harvest mesenchymal stem cells. J Bone Joint Surg Br. 2011; 93(4): 517-24[DOI][PubMed]
  • 46. Schmidmaier G, Moghaddam-Alvandi A. Was gibt es Neues 2014 in der Pseudarthrosen-Therapie? 2014;
  • 47. Cuthbert R, Boxall SA, Tan HB, Giannoudis PV, McGonagle D, Jones E. Single-platform quality control assay to quantify multipotential stromal cells in bone marrow aspirates prior to bulk manufacture or direct therapeutic use. Cytotherapy. 2012; 14(4): 431-40[DOI][PubMed]
  • 48. Fayaz HC, Giannoudis PV, Vrahas MS, Smith RM, Moran C, Pape HC, et al. The role of stem cells in fracture healing and nonunion. Int Orthop. 2011; 35(11): 1587-97[DOI][PubMed]
  • 49. Blokhuis TJ, Calori GM, Schmidmaier G. Autograft versus BMPs for the treatment of non-unions: what is the evidence? Injury. 2013; 44 Suppl 1-2[DOI][PubMed]
  • 50. Schmidmaier G, Herrmann S, Green J, Weber T, Scharfenberger A, Haas NP, et al. Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone. 2006; 39(5): 1156-63[DOI][PubMed]
  • 51. Calori GM, Colombo M, Mazza EL, Mazzola S, Malagoli E, Mineo GV. Incidence of donor site morbidity following harvesting from iliac crest or RIA graft. Injury. 2014; 45 Suppl 6-20[DOI][PubMed]
  • 52. Schmidmaier G, Wildemann B. The role of BMPs in current orthopedic practice. IBMS BoneKEy. 2009; 6(7): 244-53[DOI]
  • 53. Giannoudis PV, Kanakaris NK, Dimitriou R, Gill I, Kolimarala V, Montgomery RJ. The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions. Clin Orthop Relat Res. 2009; 467(12): 3239-48[DOI][PubMed]
  • 54. Aymar M, Ewerbeck V. 2014; : 898
  • 55. Schmidmaier G, Lucke M, Wildemann B, Haas NP, Raschke M. Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review. Injury. 2006; 37 Suppl 2-12[DOI][PubMed]
  • 56. Giannoudis PV, Chris Arts JJ, Schmidmaier G, Larsson S. What should be the characteristics of the ideal bone graft substitute? Injury. 2011; 42 Suppl 2-2[DOI][PubMed]
  • 57. Janicki P, Schmidmaier G. What should be the characteristics of the ideal bone graft substitute? Combining scaffolds with growth factors and/or stem cells. Injury. 2011; 42 Suppl 2-81[DOI][PubMed]
  • 58. Schmidmaier G, Capanna R, Wildemann B, Beque T, Lowenberg D. Bone morphogenetic proteins in critical-size bone defects: what are the options? Injury. 2009; 40 Suppl 3-43[DOI][PubMed]
  • 59. Fuchs T, Stange R, Schmidmaier G, Raschke MJ. The use of gentamicin-coated nails in the tibia: preliminary results of a prospective study. Arch Orthop Trauma Surg. 2011; 131(10): 1419-25[DOI][PubMed]
  • 60. Fuchs T, Schmidmaier G, Raschke MJ, Stange R. Bioactive-Coated Implants in Trauma Surgery. Eur J Trauma Emergency Surg. 2007; 34(1): 60-8[DOI]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments