Shafa Orthopedic Journal

Published by: Kowsar

Vanishing Bone Syndrome; A Diagnosis Dilemma: Report of a Rare Case and Literature Review

Mohammad Hassani 1 , Mohammad Javad Shariyate 1 , * , Shirin Taraz Jamshidi 1 , Mohammad Hallaj Moghaddam 1 and Farzad Omidi-Kashani 1
Authors Information
1 Mashhad University of Medical Sciences, Mashhad, Iran
Article information
  • Shafa Orthopedic Journal: 6 (1); e86418
  • Published Online: January 30, 2019
  • Article Type: Case Report
  • Received: November 15, 2018
  • Accepted: January 7, 2019
  • DOI: 10.5812/soj.86418

To Cite: Hassani M, Shariyate M J , Taraz Jamshidi S, Hallaj Moghaddam M, Omidi-Kashani F . Vanishing Bone Syndrome; A Diagnosis Dilemma: Report of a Rare Case and Literature Review, Shafa Ortho J. Online ahead of Print ; 6(1):e86418. doi: 10.5812/soj.86418.

Copyright © 2019, Shafa Orthopedic Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Gorham LW, Stout AP. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone); its relation to hemangiomatosis. J Bone Joint Surg Am. 1955;37-A(5):985-1004. [PubMed: 13263344].
  • 2. Ruggieri P, Montalti M, Angelini A, Alberghini M, Mercuri M. Gorham-Stout disease: The experience of the Rizzoli Institute and review of the literature. Skeletal Radiol. 2011;40(11):1391-7. doi: 10.1007/s00256-010-1051-9. [PubMed: 20972870].
  • 3. Hardegger F, Simpson LA, Segmueller G. The syndrome of idiopathic osteolysis. Classification, review, and case report. J Bone Joint Surg Br. 1985;67(1):88-93. [PubMed: 3968152].
  • 4. Bruch-Gerharz D, Gerharz CD, Stege H, Krutmann J, Pohl M, Koester R, et al. Cutaneous lymphatic malformations in disappearing bone (Gorham-Stout) disease: A novel clue to the pathogenesis of a rare syndrome. J Am Acad Dermatol. 2007;56(2 Suppl):S21-5. doi: 10.1016/j.jaad.2006.01.063. [PubMed: 17097379].
  • 5. Szabo C, Habre W. Gorham syndrome: Anaesthetic management. Anaesthesia. 2000;55(2):157-9. [PubMed: 10651678].
  • 6. Kiran DN, Anupama A. Vanishing bone disease: A review. J Oral Maxillofac Surg. 2011;69(1):199-203. doi: 10.1016/j.joms.2010.05.088. [PubMed: 21030127].
  • 7. Moller G, Priemel M, Amling M, Werner M, Kuhlmey AS, Delling G. The Gorham-Stout syndrome (Gorham's massive osteolysis). A report of six cases with histopathological findings. J Bone Joint Surg Br. 1999;81(3):501-6. [PubMed: 10872375].
  • 8. Hu P, Yuan XG, Hu XY, Shen FR, Wang JA. Gorham-Stout syndrome in mainland China: A case series of 67 patients and review of the literature. J Zhejiang Univ Sci B. 2013;14(8):729-35. doi: 10.1631/jzus.B1200308. [PubMed: 23897792]. [PubMed Central: PMC3735973].
  • 9. Ozbayrak M, Yilmaz MH, Kantarci F, Ozer H, Harmanci K, Babacan M, et al. A case of an idiopathic massive osteolysis with skip lesions. Korean J Radiol. 2013;14(6):946-50. doi: 10.3348/kjr.2013.14.6.946. [PubMed: 24265571]. [PubMed Central: PMC3835643].
  • 10. Boyer P, Bourgeois P, Boyer O, Catonne Y, Saillant G. Massive Gorham-Stout syndrome of the pelvis. Clin Rheumatol. 2005;24(5):551-5. doi: 10.1007/s10067-005-1088-7. [PubMed: 15827684].
  • 11. Nikolaou VS, Chytas D, Korres D, Efstathopoulos N. Vanishing bone disease (Gorham-Stout syndrome): A review of a rare entity. World J Orthop. 2014;5(5):694-8. doi: 10.5312/wjo.v5.i5.694. [PubMed: 25405099]. [PubMed Central: PMC4133478].
  • 12. Ogita S, Deguchi E, Tokiwa K, Iwata J, Kubota Y, Iwai N. Ongoing osteolysis in patients with lymphangioma. J Pediatr Surg. 1998;33(1):45-8. [PubMed: 9473098].
  • 13. Young JW, Galbraith M, Cunningham J, Roof BS, Vujic I, Gobien RP, et al. Progressive vertebral collapse in diffuse angiomatosis. Metab Bone Dis Relat Res. 1983;5(2):53-60. [PubMed: 6231451].
  • 14. Hirayama T, Sabokbar A, Itonaga I, Watt-Smith S, Athanasou NA. Cellular and humoral mechanisms of osteoclast formation and bone resorption in Gorham-Stout disease. J Pathol. 2001;195(5):624-30. doi: 10.1002/path.989. [PubMed: 11745700].
  • 15. Kose M, Pekcan S, Dogru D, Akyuz C, Ozcelik U, Ozsurekci Y, et al. Gorham-Stout syndrome with chylothorax: Successful remission by interferon alpha-2b. Pediatr Pulmonol. 2009;44(6):613-5. doi: 10.1002/ppul.20849. [PubMed: 19434689].
  • 16. Grunewald TG, Damke L, Maschan M, Petrova U, Surianinova O, Esipenko A, et al. First report of effective and feasible treatment of multifocal lymphangiomatosis (Gorham-Stout) with bevacizumab in a child. Ann Oncol. 2010;21(8):1733-4. doi: 10.1093/annonc/mdq331. [PubMed: 20605931].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments