Volume 33, Issue 1 (2-2019)                   Med J Islam Repub Iran 2019 | Back to browse issues page


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AsghariHanjani N, Vafa M. The role of IGF-1 in obesity, cardiovascular disease, and cancer . Med J Islam Repub Iran. 2019; 33 (1) :342-345
URL: http://mjiri.iums.ac.ir/article-1-4706-en.html
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran , vafa.m@iums.ac.ir
Abstract:   (644 Views)
Background: Insulin-like growth factor1 (IGF1) is a polypeptide that structurally is similar to human pro-insulin, one of the factors that is altered in obesity and many related diseases, hence a large body of research devoted to evaluate it.
   Methods: In this mini-review, we briefly explain the role of IGF1 in different conditions, including obesity, cardiovascular disease, and cancer through the results of review and original articles in both animal and human studies.
   Results: The short-term metabolic effect of IGF-1 is insulin-like, and its long-term effect is growth factor-like. IGF1 has different roles in the initiation and progression of different diseases, because in some cases, the anti-apoptotic effect, can help cell survival while in others, it may lead to cancer or increment of adipocytes.
   Conclusion: It is highly recommended to consider the different impacts of IGF1 in health and diseases prevention in future studies and interventions.
 
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Type of Study: Review Article | Subject: Nutrition

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